Dr. Rosenberg graduated from Albert Einstein College of Medicine, and trained in anesthesiology at the Hospital of the University of Pennsylvania. Following a year of laboratory fellowship training in the Pharmacology Department of the University of Pennsylvania Medical School, he served as chief of anesthesia at the U.S. Public Health System Hospital in Boston, Massachusetts. He served on the Tufts University Medical School faculty then joined the faculty of the University of Pennsylvania Medical School achieving the rank of tenured Associate Professor of Anesthesiology. In 1981, he became Chair, Department of Anesthesiology and residency program director at Hahnemann University Medical School. Following its merger with the Medical College of Pennsylvania in 1992 he was named Chair of the joint department.
In 1997 he became director of the Anesthesia residency program and Vice Chair of Academic Affairs in the Department of Anesthesiology at Thomas Jefferson University. Dr. Rosenberg serves on editorial boards of anesthesia journals, was editor in chief of American Journal of Anesthesiology, and is a senior examiner for the American Board of Anesthesiology. In 1981 he co-founded the Malignant Hyperthermia Association of the United States and served as its President. Dr. Rosenberg has over 110 peer reviewed publications and numerous abstracts and invited book chapters. In 2004, he was certified as a physician executive by the American College of Physician Executives.